P28-05 PIK3CA mutations and gene copy number in human lung cancers
نویسندگان
چکیده
منابع مشابه
PIK3CA mutations and copy number gains in human lung cancers.
We investigated the frequency and function of mutations and increased copy number of the PIK3CA gene in lung cancers. PIK3CA mutations are one of the most common gene changes present in human cancers. We analyzed the mutational status of exons 9 and 20 and gene copy number of PIK3CA using 86 non-small cell lung cancer (NSCLC) cell lines, 43 small cell lung cancer (SCLC) cell lines, 3 extrapulmo...
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Phosphatidylinositol 3-kinases (PI3Ks) are important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in human cancers, we recently analyzed the sequences of the PI3K gene family and discovered that one member, the PIK3CA gene encoding the p110alpha catalytic subunit, was frequently mutated in cancers of the colon, breast, brain and lung. The majority of muta...
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ژورنال
عنوان ژورنال: The Journal of the Japanese Association for Chest Surgery
سال: 2008
ISSN: 0919-0945,1881-4158
DOI: 10.2995/jacsurg.22.517_1